Cyprodinil 75% WDG Fungicide

Active Ingredient: Cyprodinil

CAS Number: 121552-61-2

Molecular Formula: C₁₄H₁₅N₃

Classification: Systemic fungicide from the anilinopyrimidine class

Primary Use: Controls fungal diseases in grapes, pome/stone fruits, vegetables, and cereals through systemic action.

Mode of Action

Mechanism: Inhibits fungal amino acid biosynthesis (specifically proline and glutamine production), disrupting cell wall synthesis and spore germination.
Systemic Activity: Absorbed by plant roots/foliage and translocated acropetally, providing protection to new growth and existing tissues.
Action Types: Preventive (blocks infection) and curative (stops pathogen spread in established infections).

Target Diseases & Crops

Crops	Target Diseases	Dosage (75% WDG)	Application Method	Timing
Grapes	Powdery mildew, gray mold (Botrytis)	50–75 g/ha	Foliar spray every 10–14 days	Early disease stages or preventively
Apples/Pears	Scab, powdery mildew	50–75 g/ha	Foliar spray every 7–10 days	At first sign of disease
Tomatoes	Early blight, Septoria leaf spot	50–75 g/ha	Spray every 7–10 days	Start at early growth stages
Wheat/Corn	Septoria leaf spot, gray leaf spot	50–75 g/ha	Spray every 7–14 days	Early disease cycle
Cucumbers/Lettuce	Downy mildew, gray mold	50–75 g/ha	Even coverage at first symptoms	As needed during high humidity

Formulations & Compatibility

Primary Formulation: 75% Water-Dispersible Granules (WDG)
- Advantages: Easy dilution, uniform distribution, and systemic uptake.
Other Formulations: 50% WDG, 98% Technical Grade (TC)
Tank Mixes: Compatible with fludioxonil, picoxystrobin, and insecticides (e.g., iprodione + cyprodinil mixes).

Key Features & Benefits

Broad-Spectrum Efficacy: Controls Ascomycetes and Deuteromycetes (e.g., Botrytis, Venturia, Podosphaera).
Systemic Protection: Translocates to all plant parts, ensuring coverage of new shoots and protected areas.
Dual Action: Effective against both spore germination (preventive) and mycelial growth (curative).
High Concentration: 75% active ingredient reduces application rates (0.2–0.5 kg/ha) and labor costs.
Residue Safety: Pre-harvest interval (PHI) of 7–14 days complies with food safety standards.

Application Guidelines

Mixing: Dissolve granules in 500–800 L water/ha for foliar application; stir thoroughly for uniform suspension.
Timing: Apply at first signs of disease or preventively during high-risk periods (e.g., wet weather).
Frequency: Repeat every 7–14 days based on disease pressure; maximum 3 applications per season.
Weather: Avoid spraying in rain or winds >10 km/h to prevent drift and wash-off.

Safety & Storage

Personal Protection: Wear gloves, goggles, and respiratory masks; avoid skin/eye contact.
Environmental Impact: Low toxicity to mammals, moderate risk to aquatic life (keep away from water bodies).
Storage: Store in cool, dry conditions; keep containers sealed to prevent moisture absorption.

Packaging Options

Small Scale: 1kg/bag, 5kg/bag (suitable for small farms and greenhouses).
Bulk: 25kg/drum, 200L containers, 1000L IBCs (for commercial agriculture).
Custom Solutions: OEM/ODM services for branded labeling and regional formulations.

Technical Notes

IRAC Group: 9 (anilinopyrimidines) – single-site mode of action; rotate with multi-site fungicides (e.g., mancozeb) to manage resistance.
Suitability: Not recommended for organic farming; synthetic formulation.

Cyprodinil 75% WDG Fungicide FAQ

1. What is Cyprodinil, and how does it work?

Cyprodinil is a systemic fungicide belonging to the anilinopyrimidine class (IRAC Group 9). Its molecular formula is C₁₄H₁₅N₃, and it acts by inhibiting fungal amino acid biosynthesis, specifically disrupting proline and glutamine production. This prevents cell wall synthesis and spore germination, halting both initial infection (preventive action) and pathogen spread in established infections (curative action). It is absorbed by plants and translocated acropetally (upward through the xylem), protecting new growth and existing tissues.

2. What fungal diseases does Cyprodinil control?

Cyprodinil targets a range of Ascomycete and Deuteromycete pathogens, including:

Botrytis cinerea (gray mold) in grapes, tomatoes, and strawberries.
Venturia inaequalis (apple scab) and Podosphaera leucotricha (powdery mildew) in pome fruits.
Septoria spp. (leaf spot) in wheat, corn, and vegetables.
Sclerotinia spp. (white mold) in lettuce and beans.
Monilinia spp. (brown rot) in stone fruits like peaches and cherries.

3. Which crops is Cyprodinil suitable for?

It is widely used on:

Fruits: Grapes, apples, pears, strawberries, peaches, cherries.
Vegetables: Tomatoes, cucumbers, lettuce, beans, potatoes.
Cereals: Wheat, corn, barley.
Ornamentals: Roses, greenhouse crops (e.g., ornamental flowers).

4. What is the primary formulation of Cyprodinil?

The main formulation is 75% Water-Dispersible Granules (WDG), which offers:

Easy dilution in water for uniform foliar or soil application.
Enhanced systemic uptake due to fine particle size.
Compatibility with tank mixes (e.g., with fludioxonil in products like Switch®).
Other formulations include 50% WDG and technical grade (98% TC) for custom blending.

5. How should Cyprodinil be applied?

Dosage: 50–75 g/ha (75% WDG) mixed in 500–800 L water/ha, depending on crop and disease severity.
Method:
- Foliar spray: Apply to upper and lower leaf surfaces, ensuring even coverage.
- Soil drench: For root-infecting pathogens (e.g., Sclerotinia), apply as a systemic treatment.
Timing:
- Preventive: At bud break, flowering, or before wet weather.
- Curative: At first signs of disease (e.g., small lesions or powdery growth).
Frequency: Repeat every 7–14 days; limit to 3 applications per season to avoid resistance.

6. Is Cyprodinil compatible with other pesticides?

Yes, it can be mixed with:

Strobilurins (e.g., picoxystrobin) for enhanced broad-spectrum control.
Dicarboximides (e.g., iprodione) in dual-action formulations.
Insecticides (e.g., pyrethroids) for combined pest-fungal management.
Avoid mixing with alkaline substances or products containing heavy metals (e.g., copper), as they may reduce efficacy.

7. What are the safety precautions for using Cyprodinil?

Personal Protection: Wear gloves, goggles, and a respiratory mask; avoid skin/eye contact or inhalation.
Environmental Safety:
- Toxic to aquatic life (fish, algae); keep 100 meters away from water bodies.
- Moderate soil persistence (half-life: 10–30 days); avoid overuse in sensitive ecosystems.
Storage: Store in a cool, dry place, away from food, feed, and children.

8. What is the pre-harvest interval (PHI)?

The PHI varies by crop:

Grapes/Apples: 14 days.
Tomatoes/Lettuce: 7 days.
Wheat/Corn: 10 days.
Always follow label instructions to ensure residue levels comply with food safety regulations (e.g., EU MRLs, EPA standards).

9. How to manage resistance to Cyprodinil?

As a single-site fungicide, Cyprodinil is prone to resistance if used repeatedly. Mitigation strategies include:

Rotation: Alternate with multi-site fungicides (e.g., mancozeb, copper) or unrelated classes (e.g., triazoles, strobilurins).
Tank Mixes: Use with fungicides of different modes of action (e.g., fludioxonil + cyprodinil).
Monitoring: Scout fields regularly to detect early signs of resistance (e.g., reduced efficacy despite proper application).

10. Is Cyprodinil approved for organic farming?

No. Cyprodinil is a synthetic chemical fungicide and is not permitted in organic systems. Organic alternatives include:

Biological control agents (e.g., Bacillus subtilis).
Copper-based products (limited use due to soil accumulation risks).
Sulfur (for powdery mildew in some crops).

11. How does Cyprodinil compare to other fungicides like Fludioxonil?

Feature	Cyprodinil	Fludioxonil (Phenylpyrrole)
Mode of Action	Inhibits amino acid biosynthesis	Disrupts cell membrane function
Target Diseases	Gray mold, scab, powdery mildew	Gray mold, botrytis, soil-borne fungi
Systemic Activity	High (acropetal translocation)	Limited (contact + 局部内吸)
Resistance Risk	High (single-site)	Moderate (unique mode of action)
Common Use	Foliar protection in fruits/vegetables	Post-harvest and foliar applications

12. What are the signs of phytotoxicity?

Phytotoxicity is rare when used at recommended rates, but may occur in sensitive crops or under extreme conditions:

Leaf curling or yellowing (chlorosis) in young shoots.
Stunted growth if applied at excessive doses or during heat stress.
Fruit russeting in some apple varieties if sprayed near harvest.

13. Can Cyprodinil be used in greenhouses?

Yes, it is suitable for greenhouse applications to control diseases like gray mold in tomatoes, cucumbers, and ornamental plants. Ensure proper ventilation during application to avoid operator exposure and reduce humidity-driven disease pressure.

14. What is the shelf life of Cyprodinil 75% WDG?

The shelf life is 2–3 years when stored in sealed containers at temperatures below 30°C and protected from moisture. Degradation may occur if exposed to prolonged heat or humidity, reducing efficacy.

15. Is Cyprodinil toxic to bees and other beneficial insects?

Cyprodinil has low toxicity to bees when applied as a foliar spray (LD₅₀ > 200 µg/bee), but avoid spraying during flowering to minimize direct contact. It is generally safe for ladybugs and other predatory insects when used as directed.