How It Works: Targeted Grass Control Through ACCase Inhibition
Clethodim works by inhibiting acetyl-CoA carboxylase (ACCase), an enzyme critical for fatty acid synthesis in grass weeds. Without this, the weed’s cells can’t form membranes, resulting in halted growth and eventual death.
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Broadleaf crops remain unaffected due to having a different form of the ACCase enzyme
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Symptoms like yellowing and reddening appear within 5–10 days
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Complete weed death can occur in 10–20 days, depending on species and growth stage
Application Targets: What Clethodim Controls
✅ Approved Broadleaf Crops
Use Clethodim safely on:
| Crop Category |
Examples |
| Legumes |
Soybeans, Peanuts, Alfalfa, Clover |
| Oil Crops |
Cotton, Canola, Sunflower |
| Root & Tuber Crops |
Sugar Beets, Potatoes, Carrots |
| Vegetables |
Tomato, Onion, Lettuce, Pumpkin |
| Wildlife Food Plots |
Clover, Chicory, Other Broadleaf Blends |
Yes, you can spray Clethodim on clover without harming your food plot.
Target Grass Weeds
Clethodim is effective against:
| Grass Type |
Common Names |
| Annual Grasses |
Foxtail, Barnyardgrass, Crabgrass |
| Perennial Grasses |
Johnsongrass, Bermudagrass, Quackgrass |
| Volunteer Grains |
Corn, Wheat, Barley |
| Problem Weeds |
Wild Oats, Ryegrass, Goosegrass, Lovegrass |
Product Specifications
| Property |
Details |
| Chemical Name |
(E,E)-(+/-)-2-[1-[[[(3-chloro-2-propenyl)oxy]imino]propyl]-5-[2-(ethylthio)propyl]-3-hydroxycyclohex-2-en-1-one |
| CAS Number |
99129-21-2 |
| Formula |
C₁₇H₂₆ClNO₃S |
| Formulations |
12% EC, 13% EC, 24% EC, 26% EC, 30% EC, 35% EC, 120 g/L EC, 240 g/L EC, 480 g/L EC |
| Mode of Action |
ACCase Inhibitor (fatty acid synthesis disruption) |
| Toxicity |
Low to mammals and birds; moderate to aquatic life |
| Shelf Life |
2 years |
Recommended Application Rates
| Formulation |
Use Case |
Rate |
Notes |
| 120 g/L EC |
Soybeans, peanuts, vegetables |
120–250 mL/ha |
Apply at 2–4 leaf stage of grasses |
| 240 g/L EC |
Cotton, sunflowers, clover |
150–250 mL/ha |
Apply during active growth |
| 240 g/L EC |
Potatoes, sugar beets, food plots |
180–250 mL/ha |
Avoid drought or heat-stressed weeds |
Tank Mix Tip: Add 0.5–1.0% v/v crop oil concentrate or methylated seed oil to enhance uptake.
How to Mix and Apply Clethodim
Mixing Instructions:
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Fill spray tank halfway with clean water
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Add the measured Clethodim dose
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Agitate continuously
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Add the adjuvant and remaining water
Spot Spray Mix:
Broadcast Mix:
Rainfastness & Reentry
Compatibility & Mixing Tips
Can Clethodim Be Mixed with Glyphosate?
Yes—but with caution. Glyphosate can antagonize Clethodim in stressed conditions.
If mixed:
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Slightly increase Clethodim rate
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Always add oil-based adjuvants
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Avoid cool or stressed conditions
Other compatible tank mix options: broadleaf herbicides, insecticides, and fungicides (always jar test first).
Bulk Supply for Distributors and Agricultural Professionals
Clethodim herbicide is available for:
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Summary Snapshot
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Kills: Annual and perennial grasses
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Spares: Soybeans, clover, peanuts, vegetables, and other broadleaf crops
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Best For: Precision post-emergent weed control in sensitive crops
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Formulations: Multiple EC options to suit farm size and weed pressure
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Rainfast: 1 hour
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Mix-Friendly: With most adjuvants and herbicides (verify locally)
Clethodim is a post – emergence, systemic herbicide that belongs to the cyclohexanedione family. It works by inhibiting the enzyme acetyl – CoA carboxylase (ACCase) in susceptible plants. ACCase is crucial for fatty acid synthesis, which is essential for cell membrane formation and plant growth. By blocking ACCase, Clethodim disrupts fatty acid production, leading to the breakdown of cell membranes, cessation of growth, and ultimately the death of the plant. It is primarily effective against annual and perennial grasses.
Clethodim is a grass – specific herbicide. It is designed to target grasses and has minimal effect on broadleaf plants like clover and chicory when used at recommended rates. So, under normal circumstances, it will not kill clover or chicory. However, if applied in extremely high doses or in conditions that cause phytotoxicity, there could be some damage, but this is not the intended outcome.
Yes, Clethodim can often be mixed with Glyphosate or Butyrac 200. Mixing Clethodim with Glyphosate combines the grass – killing properties of Clethodim with the broad – spectrum weed – killing ability of Glyphosate, allowing for control of both grasses and broadleaf weeds in a single application. When mixed with Butyrac 200 (2,4 – DB), which is also effective against broadleaf weeds, it can enhance broadleaf weed control while Clethodim takes care of grasses. However, it’s important to always check the product labels for specific compatibility information and follow local agricultural guidelines.
For using Clethodim in clover plots, the best application timing is when the grass weeds are actively growing and in the 2 – 6 – leaf stage. This is when the weeds are most susceptible to the herbicide. Avoid applying during periods of extreme heat, cold, or drought stress on the clover, as this can increase the risk of damage to the desired clover plants. Early morning or late afternoon applications are often preferred to reduce the potential for evaporation and drift.
Yes, Butyrac 200 and Clethodim can be mixed. The combination is useful as Butyrac 200 targets broadleaf weeds, while Clethodim controls grasses. This tank – mix allows for a more comprehensive weed control strategy in fields where both types of weeds are present. When mixing, ensure proper agitation to achieve a homogeneous solution, and follow the recommended rates for each product as specified on their labels.
Yes, Clethodim and Glyphosate can be mixed. This combination is very common in agricultural and non – crop areas for controlling a wide variety of weeds. Glyphosate is a non – selective herbicide that kills most plants it comes in contact with, while Clethodim specifically targets grasses. By mixing them, you can simultaneously control broadleaf weeds with Glyphosate and grasses with Clethodim. As with any tank – mix, always check the product labels for compatibility and follow the correct mixing and application procedures.
Both Clethodim and Sethoxydim are ACCase – inhibiting herbicides that belong to the cyclohexanedione family, and they have similar modes of action, primarily targeting grasses. However, there can be differences in their efficacy against certain grass species. Some grasses may be more sensitive to Clethodim, while others respond better to Sethoxydim. Additionally, factors such as soil type, temperature, and application rate can influence their performance. Clethodim may have a faster uptake and translocation in some plants, leading to quicker visible effects, but overall, the choice between them often depends on local weed populations and past experience with control.
Clethodim, Sethoxydim, and Fluazifop – p all belong to the ACCase – inhibiting herbicide group and are used to control grasses. Clethodim and Sethoxydim are cyclohexanediones, while Fluazifop – p is a phenoxypropionate. They have different chemical structures, which can result in variations in their activity against different grass species, rates of uptake, and environmental persistence. Fluazifop – p may be more effective against certain annual grasses in some situations, while Clethodim and Sethoxydim can offer good control of a wide range of annual and perennial grasses. The choice among them depends on the specific grass weeds present, the crop being grown, environmental conditions, and resistance management considerations.
No, Clethodim should not be sprayed directly on pumpkins. Pumpkins are broadleaf plants, and although Clethodim is mainly grass – selective, it can cause significant damage to pumpkin plants if it comes in contact with them. If grass control is needed in pumpkin fields, care must be taken to apply Clethodim in a way that avoids overspray or drift onto the pumpkins, such as using a shielded sprayer or spot – treating grassy areas away from the crop.
Yes, Clethodim can be sprayed on soybeans. It is a commonly used herbicide in soybean fields to control grassy weeds. However, it must be applied according to the label instructions. Typically, it is applied post – emergence when the grass weeds are in the appropriate growth stage (usually 2 – 6 leaves). Using the correct rate and application method helps ensure effective grass control without causing excessive damage to the soybean crop. Some soybean varieties may have better tolerance to Clethodim, so it’s important to consider the specific variety being grown.
Clethodim can be used in sunflower fields for grass control, but with caution. Sunflowers can vary in their tolerance to Clethodim, and it’s essential to follow the product label and local agricultural recommendations. It should be applied when the grass weeds are small and actively growing, and care should be taken to avoid drift and overspray onto the sunflowers. Some sunflower hybrids may be more sensitive than others, so it may be advisable to test a small area first before a full – field application.
Clethodim herbicide is primarily used for post – emergence control of annual and perennial grasses in a variety of crops, including soybeans, peanuts, cotton, and in non – crop areas like pastures, roadsides, and industrial sites. It helps to reduce competition from grassy weeds, allowing the desired crops or vegetation to grow without being outcompeted. In addition, it can be used in food plots for wildlife, where it selectively removes grasses to favor the growth of broadleaf forage plants like clover and chicory.
Clethodim is specifically designed to kill grasses. It is effective against a wide range of annual grass species, such as crabgrass, foxtail, and barnyardgrass, as well as many perennial grasses like bermudagrass, quackgrass, and johnsongrass. It targets these grasses by inhibiting the ACCase enzyme, which disrupts their growth and ultimately leads to death. It has little to no effect on broadleaf plants when used at the recommended rates.
No, Clethodim is a grass – specific herbicide, and when used at the recommended application rates, it will not kill clover. Clover is a broadleaf plant, and Clethodim’s mode of action targets the ACCase enzyme in grasses, leaving broadleaf plants like clover unharmed. This makes it a useful herbicide for maintaining clover in food plots or pastures while controlling unwanted grassy weeds.
Chicory is a broadleaf plant, and like clover, Clethodim will not kill chicory when applied at the recommended rates. Its selective action against grasses allows chicory to remain unharmed, making it suitable for use in areas where chicory is the desired forage or ornamental plant, and grass control is needed.
Clethodim can potentially harm sunflowers. Sunflowers are broadleaf plants, and although Clethodim is mainly grass – selective, direct contact with sunflowers can cause phytotoxicity. The extent of damage depends on factors such as the rate of application, the growth stage of the sunflowers, and the environmental conditions at the time of application. To avoid damage, special care must be taken when using Clethodim in or around sunflower fields.
In clover plots, Clethodim is used to control grassy weeds that can compete with the clover for nutrients, water, and sunlight. By selectively removing grasses, it allows the clover to thrive. The best time to apply Clethodim is when the grass weeds are in the 2 – 6 – leaf stage and actively growing. Using the correct rate, which may vary depending on the severity of the grass infestation and the formulation of Clethodim, ensures effective grass control without harming the clover.
Clethodim herbicide is a valuable tool for maintaining healthy clover stands. It targets and eliminates grassy weeds that would otherwise outcompete the clover. When applying Clethodim to clover, it’s important to use a non – ionic surfactant as recommended on the label to enhance the herbicide’s effectiveness. The application should be made under favorable weather conditions, avoiding extreme heat, cold, or windy days to minimize the risk of drift and ensure proper coverage of the grass weeds.
Clethodim can be used to control bermudagrass, especially in non – crop areas or in situations where bermudagrass is considered a weed. Bermudagrass is a perennial grass, and repeated applications of Clethodim may be required to achieve complete control, as it can regrow from rhizomes and stolons. It’s most effective when applied to actively growing bermudagrass, and using a higher rate may be necessary for more established infestations. However, in some crops, care must be taken to avoid damage to the crop while targeting bermudagrass.
The rate of Clethodim herbicide per acre can vary depending on several factors, including the formulation of the herbicide, the type and size of the grass weeds, and the crop or area being treated. Generally, for post – emergence control of annual grasses in crops like soybeans, the rate may range from 4 – 8 fluid ounces per acre of a 2 – quart per gallon formulation. For more difficult – to – control perennial grasses, higher rates may be required, often in the range of 8 – 12 fluid ounces per acre. Always refer to the product label for the specific recommended rate for your situation.
For clover plots, when using Clethodim to control grassy weeds, a common rate is around 4 – 6 fluid ounces per acre of a 2 – quart per gallon formulation. However, this can vary depending on the density and type of grass weeds present. If the grass infestation is severe or the grass species are more resistant, a higher rate within the recommended range on the label may be needed. As with any herbicide application, it’s crucial to follow the label instructions precisely to avoid harming the clover.
When using Clethodim in sunflower fields for grass control, the rate should be carefully determined based on the sunflower variety’s tolerance and the grass weed pressure. A typical starting rate might be 4 – 6 fluid ounces per acre of a 2 – quart per gallon formulation, but this may need to be adjusted. It’s advisable to consult local agricultural extension services or the herbicide manufacturer for specific recommendations tailored to the sunflower variety and local growing conditions to minimize the risk of damage to the sunflowers.
The mix ratio of Clethodim herbicide depends on the formulation and the rate of application per acre. For example, if using a 2 – quart per gallon formulation and the recommended rate is 6 fluid ounces per acre, and you are making a 10 – acre batch, you would need 60 fluid ounces (or 3.75 pints) of Clethodim. This would be mixed with the appropriate amount of water, usually several gallons per acre, depending on the sprayer’s capacity and the desired coverage. Always refer to the product label for the correct mix ratio based on your specific application requirements.
Clethodim is generally considered rainfast within 2 – 4 hours after application. Once the herbicide has had time to be absorbed by the grass leaves, rainfall is less likely to wash it off and reduce its effectiveness. However, if it rains heavily within the first 2 – 4 hours, reapplication may be necessary to ensure proper weed control. Environmental factors such as wind and humidity can also affect the rainfastness, so it’s best to apply Clethodim when rain is not expected for at least 4 hours.
Visible signs of Clethodim’s action can usually be observed within 2 – 5 days after application. Grasses will start to show signs of wilting, yellowing, and stunted growth. However, complete kill of the grass weeds may take 1 – 3 weeks, depending on factors such as the grass species, the size of the weeds, environmental conditions (temperature, moisture), and the rate of application. Warmer temperatures and adequate moisture can speed up the process, while cooler or dry conditions may slow it down.
It typically takes 1 – 3 weeks for Clethodim to kill grass completely. After application, the grass will initially show symptoms like wilting, discoloration, and reduced growth within 2 – 5 days. Over the next 1 – 2 weeks, the plant’s physiological processes are further disrupted due to the inhibition of ACCase, leading to the death of the grass. Perennial grasses may take longer to die completely, especially if they have extensive root systems or rhizomes that need to be exhausted of stored nutrients.
The optimal time to spray Clethodim on clover is when the grass weeds in the clover plot are in the 2 – 6 – leaf stage and actively growing. This is when the weeds are most vulnerable to the herbicide. Avoid spraying during periods of high stress on the clover, such as during drought, extreme heat, or cold spells. Early morning or late afternoon, when the temperature is more moderate and there is less wind, is often the best time of day for application to ensure proper coverage and minimize drift.
When applying Clethodim to clover, first, calculate the correct amount of herbicide based on the area to be treated and the recommended rate. Mix the Clethodim with water in a sprayer, adding a non – ionic surfactant as per the label instructions to improve the herbicide’s adhesion and absorption. Then, spray the mixture evenly over the clover plot, focusing on the areas where grass weeds are present. Ensure good coverage of the grass leaves without overspraying onto the clover plants. After application, avoid disturbing the treated area for at least a few hours to allow the herbicide to be absorbed.
Clethodim’s mode of action involves the inhibition of the acetyl – CoA carboxylase (ACCase) enzyme in susceptible plants. ACCase is responsible for the first committed step in fatty acid synthesis, which is essential for the production of cell membranes, waxes, and other lipid – containing structures in plants. By blocking ACCase, Clethodim prevents the synthesis of fatty acids, leading to the breakdown of cell membranes, disruption of normal plant growth processes, and ultimately the death of the grass plant. It is absorbed by the leaves of the grass weeds and translocated throughout the plant, ensuring that all parts are affected by the herbicide.
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